Skin Aging

 1. Causes of skin aging

Main Cause: UV Damage

Intrinsic Causes

With the physiological changes produced by age / physical condition, such as Disease, Metabolic Rate, Hormonal Status and Glycation.

External Causes

Affected by the external environment / bad habit, e.g., such as Air and Environmental Pollution, Smoking , Excess Alcohol Consumption, Malnutrition, Lack of rest / stress.

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58 years old female who always expose under the sun

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72 years old male monk, in his life, he stays indoor and less expose to the sunlight

 

1.1 Free Radical Injury

Mechanism of free radical injury:

  1. A free radical finds a combination of electronic.
  2. Steals electron from the cell membrane and binds to it.
  3. Damages cell membranes.
  4. Destroys electronics group, starts a chain reaction of free radical activity.

 

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The Membrane Hypothesis of aging — Dr. Nagy

1.2 Free Radicals Damage

Consequences of free radicals damage:

  • Damage cell membranes, thus destructive enzymes and pollutants enter the cells
  • Damage DNA can lead to cellular mutations
  • Damage the collagen fibers of the skin

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